Once a day theophylline; serum concentrations.
نویسندگان
چکیده
Twenty four hour profiles of serum theophylline concentrations were examined in 15 asthmatic children taking a new theophylline preparation once a day. Peak concentrations occurred at a time when nocturnal wheezing is likely. Fluctuation in concentrations throughout the day was greater than with other currently available preparations, but the importance of this has yet to be determined.
منابع مشابه
Bioavailability of a once daily-administered theophylline preparation. A comparison study.
To evaluate the bioavailability of a new theophylline preparation suitable for once-a-day (od) oral administration, we performed a nonrandomized crossover study in which the absorption of the OD and a standard twice-a-day (bid) preparation were compared. Eight stable asthmatic patients, after having achieved steady-state, received an average of 975 mg of OD preparation at 8 PM. The protocol was...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 59 8 شماره
صفحات -
تاریخ انتشار 1984